Endocrinology and Metabolism

Seong Chul Kim (Kim SC)

3 Articles

Long-Term Survival of a Patient with Pulmonary Artery Intimal Sarcoma after Sequential Metastasectomies of the Thyroid and Adrenal Glands: Yun Mi Choi, Eun Kyung Jang, Seong Hee Ahn, Min Ji Jeon, Ji Min Han, Seong Chul Kim, Duck Jong Han, Gyungyup Gong, Tae Yong Kim, Young Kee Shong, Won Bae Kim; Endocrinol Metab. 2013;28(1):46-49. Published online March 25, 2013; DOI: https://doi.org/10.3803/EnM.2013.28.1.46

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Cancer metastases to the thyroid or adrenal gland are uncommon. Furthermore, cases showing long-term survival after surgical resection of those metastatic tumors are rare. We report a case of pulmonary artery intimal sarcoma with metastases to the thyroid and adrenal glands sequentially that was successfully treated with sequential metastasectomies. A 62-year-old woman presented with a 4-week history of dyspnea on exertion and facial edema in November 1999. Echocardiography and chest computed tomography (CT) revealed an embolism-like mass in the pulmonary trunk. Pulmonary artery endarterectomy with pulmonary valve replacement was performed, and histopathology revealed pulmonary artery intimal sarcoma. A thyroid nodule was found by chest CT in November 2001 (2 years after initial surgery). During follow-up, this lesion showed no change, but we decided to obtain fine needle aspiration cytology (FNAC) in August 2004 (4.7 years after initial surgery). FNAC revealed atypical spindle cells suggestive of metastatic intimal sarcoma. She underwent total thyroidectomy. During follow-up, a right adrenal gland mass was detected by chest CT in March 2006 (6.3 years after initial surgery), and adrenalectomy was done, which also revealed metastatic sarcoma. She has been followed up without any evidence of recurrent disease until May 2012 (12.5 years after initial surgery).

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Reoperation of Pulmonary Artery Intimal Sarcoma for Recurrence After Pulmonary Artery Replacement
Kentaro Miyazaki, Isao Matsumoto, Satoshi Nishikawa, Takashi Wada, Tetsuya Takayama, Daisuke Saito, Shuhei Yoshida, Kenji Iino, Hirofumi Takemura
Annals of Thoracic Surgery Short Reports.2024;[Epub] CrossRef
Pulmonary artery sarcoma: An important mimic of pulmonary embolism—Case reports and literature review
Colin Tuft, Krishan Maheepala, Ajantha Raguparan, Anas Naeem, Suhrid Lodh, Steven Lindstrom
Respirology Case Reports.2022;[Epub] CrossRef
Rare case of metastatic liposarcoma to the thyroid gland and a review of the literature of metastatic sarcomas to the thyroid
Monica H. Xing, Neil Mundi, Aparna Govindan, Azita Khorsandi, Margaret Brandwein‐Weber, Ammar Matloob, Bobby Liaw, Mark L. Urken
Head & Neck.2021;[Epub] CrossRef
Left pneumonectomy with pulmonary arterioplasty under cardiopulmonary bypass for pulmonary artery intimal sarcoma
Akihiko Kitahara, Yuki Shimizu, Tatsuya Goto, Seijiro Sato, Terumoto Koike, Masanori Tsuchida
The Journal of the Japanese Association for Chest Surgery.2018; 32(4): 492. CrossRef
Intimal sarcoma of the pulmonary artery with multiple lung metastases: Long-term survival case
Sonia García-Cabezas, Macarena Centeno-Haro, Simona Espejo-Pérez, Elvira Carmona-Asenjo, Alberto L Moreno-Vega, Rosa Ortega-Salas, Amalia Palacios-Eito
World Journal of Clinical Oncology.2017; 8(4): 366. CrossRef
Clinical Characteristics and Treatment Outcomes of Primary Pulmonary Artery Sarcoma in Korea
Yunkyoung Lee, Hyun Jung Kim, Heeyoung Yoon, Chang-Min Choi, Yeon-Mok Oh, Sang-Do Lee, Chae-Man Lim, Woo-Sung Kim, Younsuck Koh, Jae Seung Lee
Journal of Korean Medical Science.2016; 31(11): 1755. CrossRef
An Extraordinary Case of Mesenchymal Chondrosarcoma Metastasis in the Thyroid
Santiago Ortiz, Francisco Tortosa, Manuel Sobrinho Simões
Endocrine Pathology.2015; 26(1): 33. CrossRef
Presentation and management of pulmonary artery sarcoma
Han Hsi Wong, Ioannis Gounaris, Ann McCormack, Marius Berman, Dochka Davidson, Gail Horan, Joanna Pepke-Zaba, David Jenkins, Helena M Earl, Helen M Hatcher
Clinical Sarcoma Research.2015;[Epub] CrossRef
Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef

Effects of Peroxisome Proliferator-Activated Receptor (PPAR) Delta on the Growth and Invasion of a Thyroid Cancer Cell Line.: Won Gu Kim, Hyun Jeung Choi, Eui Young Kim, Tae Yong Kim, Won Bae Kim, Seong Chul Kim, Young Kee Shong; J Korean Endocr Soc. 2009;24(1):25-32. Published online March 1, 2009; DOI: https://doi.org/10.3803/jkes.2009.24.1.25

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Abstract PDF: BACKGROUND
Peroxisome proliferator-activated receptor delta (PPAR-delta) is a ligand-activated nuclear transcription factor that is associated with many diseases, such as diabetes, obesity, metabolic syndrome, and cancer. However, the function of PPAR-delta is controversial in carcinogenesis since its ligands may inhibit or promote the growth of cancer cells. The purpose of this study was to determine the effect of GW501516, the specific agonist of PPAR-delta, in the growth and invasiveness of thyroid cancer cell lines by modulation of the target genes, ANGPTL-4 and MCP-1. METHODS: Three kinds of human cancer cell lines, FRO (thyroid anaplastic carcinoma), NPA (melanoma), and ARO (colon cancer) were treated with GW501516 in serum-free media. Cell viability was assayed using a colorimetric cell counting kit-8 assay. The changes in the level of expression of PPAR-delta and its target genes, angiopoietin-like protein-4 (ANGPTL-4) and monocyte chemotactic protein-1 (MCP-1), were determined by RT-PCR analysis and invasiveness was assessed by a cell invasion assay kit. RESULTS: GW501516 inhibited the cell growth of cancer cell lines in a dose-dependent manner and modulated the stimulation of ANGPTL-4, as well as inhibition of MCP-1. These effects were more prominent in NPA and ARO, but less effective in the thyroid cancer cell line, which had higher PPAR-delta and lower ANGPTL-4 mRNA levels. The inhibitory effects of GW501516 on cancer invasiveness had a similar pattern. CONCLUSION: The activation of PPAR-delta by GW501516 reduced the cell growth and invasiveness of the thyroid cancer cell line. This effect of GW501516 was associated with a stimulatory effect of ANGPTL4 and an inhibitory effect of MCP-1 in cancer cell lines. GW501516 was less effective in the thyroid cancer cell line, which had a low basal ANGPTL-4 mRNA level. The findings of our study serve as an impetus for further studies to elucidate the precise role of ANGPTL-4 and PPAR-delta in carcinogenesis.

Trends Analysis of Characteristics of Thyroid Cancer Patients in One Medical Center.: Seung Hun Lee, Tae Yong Kim, Jin Sook Ryu, Gyungyub Gong, Won Bae Kim, Seong Chul Kim, Suck Joon Hong, Young Kee Shong; J Korean Endocr Soc. 2008;23(1):35-43. Published online February 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.1.35

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Abstract PDF

BACKGROUND
The incidence of thyroid cancer is rapidly increasing. The aim of this study is to examine time trends in the characteristics of thyroid cancer and to determine the cause of the increase of thyroid cancer. METHODS: We evaluated 4,646 patients that underwent surgery at the Asan Medical Center for thyroid cancer between 1995 and 2006. Patients were evaluated concerning the histology, size of the primary tumor, sex, and age at the time of surgery. RESULTS: Surgically treated case of thyroid cancer increased from 91 in 1995 to 960 in 2006-a 10.5-fold increase during the 12-year period. Based on the histological categories, the proportion of papillary thyroid carcinomas (PTCs) increased from 79.1% to 94.5% during the 12-year period. According to the primary tumor size in the PTCs, the proportion of PTCs measuring 1 cm or smaller increased from 14% to 56% during the 12-year period. Whereas the proportion of PTCs measuring from 1 cm to 2 cm were similar (between 31% and 41% during the 12-year period), the proportion of PTC measuring from 2 cm to 4 cm decreased from 51% to 11% during the 12-year period. Thyroid cancer affected women more often than men by a ratio of 3.7. PTC was most common in patients in their forties, especially among women. CONCLUSIONS: The increasing number of surgically treated cases of thyroid cancer is predominantly due to an increase of papillary thyroid cancer measuring 1 cm or less. These trends suggest that the increase in surgically treated cases of thyroid cancer reflects increased detection of occult thyroid cancer due to advances in medical surveillance of impalpable nodules rather than a true increase in the number of thyroid cancers.

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A Case Report on Papillary Thyroid Cancer Patients after Thyroidectomy Treated with Korean Medicine and Immunotherapy
Eun-Bi Ko, Kwon-Jun Jang, Jung-min Yang, Jae-sung Oh
The Journal of Internal Korean Medicine.2021; 42(5): 746. CrossRef
Public perceptions of changing the terminology for low-risk thyroid cancer: a qualitative focus group study
Brooke Nickel, Caitlin Semsarian, Ray Moynihan, Alexandra Barratt, Susan Jordan, Donald McLeod, Juan P Brito, Kirsten McCaffery
BMJ Open.2019; 9(2): e025820. CrossRef
Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)
Jae Hoon Moon, Ji-hoon Kim, Eun Kyung Lee, Kyu Eun Lee, Sung Hye Kong, Yeo Koon Kim, Woo-jin Jung, Chang Yoon Lee, Roh-Eul Yoo, Yul Hwangbo, Young Shin Song, Min Joo Kim, Sun Wook Cho, Su-jin Kim, Eun Jae Jung, June Young Choi, Chang Hwan Ryu, You Jin Lee
Endocrinology and Metabolism.2018; 33(2): 278. CrossRef
Temporal Trends in the Presentation, Treatment, and Outcome of Medullary Thyroid Carcinoma: An Israeli Multicenter Study
Dania Hirsch, Orit Twito, Sigal Levy, Gideon Bachar, Eyal Robenshtok, David J. Gross, Haggi Mazeh, Carlos Benbassat, Simona Grozinsky-Glasberg
Thyroid.2018; 28(3): 369. CrossRef
Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area
Hye Jeong Kim, Na Kyung Kim, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Yong-Ki Min, Sun Wook Kim, Jae Hoon Chung
European Journal of Nutrition.2017; 56(3): 965. CrossRef
Clinical Analysis of Elderly Thyroid Cancer Patients Following Thyroidect
Keun Hee Lee, Hak Hoon Jun, Jong Woo Kim, Seung Ki Kim, Jin Hyung Heo
Korean Journal of Endocrine Surgery.2016; 16(4): 89. CrossRef
Use of CD56 and cyclin D1 in differentiating thyroid hyperplasia from papillary thyroid carcinoma
Maha E. Salama, Wael S. Ibrahim
Egyptian Journal of Pathology.2016; 36(1): 39. CrossRef
Clinical Analysis of Elderly Thyroid Cancer Patients Following Thyroidect
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A Closer Look at Papillary Thyroid Carcinoma
Won Bae Kim
Endocrinology and Metabolism.2015; 30(1): 1. CrossRef
Korea's Thyroid-Cancer “Epidemic” — Screening and Overdiagnosis
Hyeong Sik Ahn, Hyun Jung Kim, H. Gilbert Welch
New England Journal of Medicine.2014; 371(19): 1765. CrossRef
Standardized Thyroid Cancer Mortality in Korea between 1985 and 2010
Yun Mi Choi, Tae Yong Kim, Eun Kyung Jang, Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Endocrinology and Metabolism.2014; 29(4): 530. CrossRef
The Association Between the Socioeconomic Status and Thyroid Cancer Prevalence; Based on the Korean National Health and Nutrition Examination Survey 2010-2011
Seong-Woo Choi, So-Yeon Ryu, Mi-ah Han, Jong Park
Journal of Korean Medical Science.2013; 28(12): 1734. CrossRef
Burden of cancer in Korea during 2000–2020
Jae-Hyun Park, Kwang-Sig Lee, Kyu-Sik Choi
Cancer Epidemiology.2013; 37(4): 353. CrossRef
Changes in the Clinicopathological Characteristics and Outcomes of Thyroid Cancer in Korea over the Past Four Decades
Bo Youn Cho, Hoon Sung Choi, Young Joo Park, Jung Ah Lim, Hwa Young Ahn, Eun Kyung Lee, Kyung Won Kim, Ka Hee Yi, June-Key Chung, Yeo-Kyu Youn, Nam Han Cho, Do Joon Park, Chang-Soon Koh
Thyroid.2013; 23(7): 797. CrossRef
Diagnostic value of decreased expression of CD56 protein in papillary carcinoma of the thyroid gland
Won Young Park, Seong Muk Jeong, Jung Hee Lee, Hyun Jeong Kang, Dong Hun Sin, Kyung Un Choi, Do Youn Park, Gi Yeong Huh, Mee Young Sol, Chang Hun Lee
Basic and Applied Pathology.2009; 2(2): 63. CrossRef

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